The story of enzymes is as fascinating in its details as it is amazing in its applications in promoting human health and wellbeing. Enzymes are proteins that are an integral part of Nature. In fact, life without enzymes would not be possible. Enzymes are needed for each and every chemical reaction that make life possible. No vitamin, mineral or hormone can exert its beneficial effects in the human body without the involvement of enzymes. Despite their central role in all bodily functions, it is only now that the full import of enzymes in human health and disease has begun to be fully appreciated. MUCOS Pharma, the pioneer in systemic enzyme therapy, has been the standard bearer for the last fifty years in having paved the way to elucidate the function of enzymes, and their use as an oral systemic therapy. The history of enzyme research reads quite like a detective story, as diligence of dedicated scientists tested the secrets of enzyme function and developed preparations to alleviate human pain and suffering. It all started with a simple question: What are the enzymes? Years, even decades, of work finally yielded insights into the architecture of enzymes, which is beguiling in its simplicity and elegance, yet embodies the intricacies of their function. What are Enzymes: Enzymes are proteins composed of amino acids, the basic building blocks of life, arranged in chains that spontaneously fold into three-dimensional structures. These three-dimensional structures confer specificity of function. Whereas all enzymes are proteins, not all proteins are enzymes. Enzymes are involved in nearly all metabolic and physiological processes in the body. Thus, they are a key in the maintenance of a strong immune system, a robust cardiovascular tree,a healthy and intact central nervous system, and optimal hormonal balance in the body. The body produces its own supply of enzymes in requisite amounts, as and when they are needed. The enzymes, however, do get ''used up'' at rates faster than the body can replenish its supplies under a variety of conditions, such as consumption of ''junk'' foods or intake of medicines. In fact, with advancing years, the body loses its ability to produce sufficient amounts of enzymes to keep up the demands of the body imposed by metabolic attrition. This insufficiency is the root cause of susceptibility to chronic and age-related diseases. Given that enzymes are required in all cells of the body to assist in chemical reactions, they participate in a myriad of reactions that allow organs, tissues and glands to function optimally and thrive. If the body is imagined as an efficient chemical factory, it is the enzymes that fuel each and every reaction in that factory. As such, enzymes function as catalysts. That is, they make things work at a faster rate. The reason enzymes are needed for bodily functions is that, in their absence, most of the physiological processes would either not take place, or would proceed at an excruciatingly slow